Mechanisms mediating CCK-8S-induced contraction of proximal colon in guinea pigs
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چکیده
منابع مشابه
Signal transduction pathways mediating CCK-induced gallbladder muscle contraction.
The signal transduction that mediates CCK-induced contraction of gallbladder muscle was investigated in the cat. Contraction was measured by scanning micrometry in single muscle cells isolated enzymatically with collagenase. Production ofd- myo-inositol 1,4,5-trisphosphate (IP3) and sn-1,2-diacylglycerol (DAG) was quantitated using HPLC and TLC, respectively. Protein kinase C (PKC) activity was...
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We investigated the functional effects of epidermal growth factor (EGF) on guinea pig airways in vitro. EGF (3 ng/ml to 1 !-tg/ml) induced a concentration-dependent contraction in epithelium-denuded strips. The average of maximal contractions was 0.64±0.1 g (mean±S.E., for n=27), which was 72.0±9.5% of 100 mM KCI-induced contraction. The ECso was 12.3±1.6 ng/ml. The presence of epithelium signi...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2010
ISSN: 1007-9327
DOI: 10.3748/wjg.v16.i9.1076